DefinePK

Research Objective

To analyze the application efficiency of two tracers (nano activated carbon and methylene blue suspension injection) for sentinel lymph node mapping in patients with endometrial cancer.

Methodology

Retrospective analysis of medical records of 62 endometrial cancer patients treated between July 2019 and July 2021. Patients were divided into two groups: 29 received methylene blue suspension injection and 33 received nano activated carbon suspension injection. Sentinel lymph nodes were identified and stained. The study recorded the staining of sentinel lymph nodes and analyzed the application efficiency of the two tracers, including detection rate, average number of sentinel lymph nodes, bilateral detection rate, detection accuracy, positive predictive value, sensitivity, incidence of complications, tracing time, and total duration. Statistical analysis was performed using SPSS 22.0 with t-tests and chi-square tests.

Methodology Flowchart

                        graph TD
    A["Select Endometrial Cancer Patient Records July 2019 - July 2021"] --> B["Divide Patients into Two Groups"];
    B --> C["Methylene Blue Group n=29"];
    B --> D["Nano Activated Carbon Group n=33"];
    C --> E["Administer Methylene Blue Tracer"];
    D --> F["Administer Nano Activated Carbon Tracer"];
    E --> G["Map and Trace Sentinel Lymph Nodes"];
    F --> G;
    G --> H["Record Staining and Analyze Efficiency"];
    H --> I["Compare Detection Rates, Accuracy, Time, etc."];
    I --> J["Statistical Analysis SPSS 22.0"];
    J --> K["Draw Conclusions"];                    

Discussion

The study suggests that nano activated carbon is a more effective tracer for sentinel lymph node mapping in endometrial cancer patients due to its superior detection rates and accuracy. While tracing time is shorter with nano activated carbon, the total procedure duration is longer, potentially allowing for more thorough examination. The findings are supported by previous research on carbon nanoparticles and methylene blue in other cancer types.

Key Findings

Nano activated carbon suspension injection demonstrated significantly higher total detection rate, average number of sentinel lymph nodes, and bilateral detection rate compared to methylene blue suspension injection (P<0.05). Detection accuracy, positive predictive value, and sensitivity were also significantly higher with nano activated carbon (P<0.05). The incidence of complications was similar between the two groups (P>0.05). Tracing time was significantly lower with nano activated carbon, while the total duration was significantly higher (P<0.05).

Conclusion

Nano activated carbon provides a good detection effect for sentinel lymph node recognition in endometrial cancer patients, characterized by a shorter tracing time and a longer total duration compared to methylene blue suspension. This offers a basis for more effective clinical treatment approaches.

Fact Check

1. Patient Numbers: The study included a total of 62 patients, with 29 receiving methylene blue and 33 receiving nano activated carbon.
2. Timeframe: Patient records were selected from July 2019 to July 2021.
3. Statistical Significance: P<0.05 was considered statistically significant for most comparisons between the two tracers.

Mind Map