DefinePK

Abstract

Actinic cheilitis (AC) is a chronic inflammatory disease, considered the main precancerous lesion of the lip, due to it antecedents squamous cell carcinoma (SCC). AC pathogenesis is related to ultraviolet radiation (UVR) chronic exposure with persistent elastosis, but genetic predisposition also has been proved. Multiple therapies have been used with moderate success, being recently proposed photodynamic therapy (PDT). We want to report a case which although is not rare; it was treated with an innovative therapy (PDT). A 28-year-old male consulted for a 9-month evolution history characterized by recurrent lip dryness, ulcers and fissures. At the physical exam an erythematous plaque with hyperkeratotic edge of the lower lip was observed. Histological study revealed an AC with moderate dysplasia. Two sessions of PDT with methyl aminolevulinate (METVIX) and red light were performed, with excellent clinical and histological response. Control biopsy demonstrated non-dysplastic AC. We propose that PDT is a new and effective non-invasive available option for treatment of AC.