DefinePK

Abstract

Background: Patients with cystic fibrosis (CF) who have recurrent bacterial lung infections eventually develop respiratory incompetency, which increases morbidity and death. It's important to treat these patients promptly to achieve positive results.Objective: To explore the Antimicrobial sensitivity pattern of pediatric cystic fibrosis patients.Methodology: This observational study was conducted from April 2022 to September 2022 at the Department of Paediatric Medicine, Qazi Hussain Ahmad Medical Complex, Nowshera, Pakistan. Regarding the health status of pediatric CF patients, extensive evaluations were conducted as part of the diagnostic evaluation and data-gathering procedure for this study. Physical examination and laboratory testing like culture and sensitivity were performed. To evaluate the antimicrobial sensitivity pattern Kirby Bauer modified disc diffusion method was used. Version 26 of the SPSS software was used to carry out the statistical analysis. The p-value level of 0.05 has been defined as a measure of statistical significance.Results: A total of 84 children with CF symptoms were included in the research. Of these patients, there were 28 females (33.3%) and 56 boys (66.6%). Among the respiratory samples taken from pediatric CF patients, the most prevalent isolated bacteria was Pseudomonas aeruginosa (36%) followed by Klebsiella pneumonia (22.9%). Among all bacterial strains, Ciprofloxacin and Levofloxacin had the highest levels of antimicrobial sensitivity, whereas Amoxicillin, Erythromycin, and Rifampicin showed significant resistance.Conclusion: Our study concludes that P. aeruginosa was the most prevalent isolated bacteria followed by Klebsiella pneumonia in patients with cystic fibrosis. The most effective antimicrobial agents in our study were ciprofloxacin and levofloxacin.