DefinePK

Abstract

Objective: To see the additional benefit of combined nebulization with salbutamol and ipratropium bromide verses salbutamol alone in Acute Severe Asthmatic (ASA) patients.Goal: To determine whether Ipratropium bromide augments the bronchodilator effect of dose of salbutamol in acute severe asthmatic patients.Methods: Sixty asthmatics in the age range 18 to 60 years were divided into two equal groups.Group A (control group) were nebulized with salbutamol in a dosage of 2.5mlmixed with 2ml normal saline (sodium chloride) solution, and in another GroupB (treatment group), were nebulized with combined salbutamol 2.5mg andipratropium bromide 500 mcg diluted with 2 ml of normal saline solution atevery 30 minutes interval. PFT (Pulmonary Function Test) performed at 30minutes and 60 minutes.Results: The mean absolute difference in (FEV at 30 minutes was 150 ± 24 ml in favour of combined group-B, when compared with the salbutamol alone (group-A).Conclusion: Combined nebulization with salbutamol and Ipratropium Bromide is more beneficial than salbutamol alone in acute severe asthma.