DefinePK

Abstract

The resistance of insects to insecticides is one of the most pressing problems of our time. The study of resistance mechanisms is an important link in addressing a whole range of fundamental and practical problems of modern biology. The long-term and intensive use of insecticidal products was caused by the resistance development of different insect populations. Exposure to insecticides results in oxidative stress and changes in the antioxidant status of insects. The current review was aimed to accumulate the results of studies of neurotoxic insecticides in terms of their impacts on the parameters of the insect antioxidant system. Literature sources were searched by utilizing electronic databases. The gathered information was studied and structured. The review characterizes the insect antioxidant system, classifies insecticides by mechanism of action, and demonstrates the link between insecticide exposure and oxidative stress. The results show that insecticides with different active ingredients can have a significant effect on the antioxidant status of insects of different species. In some cases, this is manifested by an increase in activities of enzymes and in other cases – by a decrease. Thus, the stimulation of oxidative stress and the impairment of insect antioxidant capacity are the toxicity mechanisms of most insecticides.. Keywords: Insects; Insecticide Resistance; Insecticides; Antioxidant System; Oxidative Stress; Lipid Peroxidation; Enzymes; Reactive Oxygen Species