DefinePK

Abstract

Objective : The aim of this study was to investigate the relationship between vitamin D quantities and anti-thyroid peroxidase antibodies (anti-TPO) in Iraqi hypothyroidism patients and healthy individuals, using statistical analyses including the Cs-T, t-test, and P-values. Methods: This study collected samples from hypothyroidism patients and healthy individuals as the control group. Statistical analyses were conducted using the Cs-T, t-test, and P-values to compare the results of vitamin D quantities and anti-TPO levels between the two groups. Results: The study found no statistically significant difference in the number of AA and AC genotypes between the two groups (p = 0.21 at a significance level of 0.05). However, a significant difference was observed in the quantity of CC, CT, and TT genotypes (p = 0.02). The mean vitamin D levels in healthy individuals were significantly different from those with thyroid gland conditions (p = 0.010), and there was a significant difference in the mean anti-TPO levels in the serum of healthy individuals and individuals with thyroid disorders (p < 0.0001). The correlation coefficient suggested a converse relationship between vitamin D concentration and anti-TPO concentration in both healthy individuals and those with autoimmune-thyroid conditions.