DefinePK

Abstract

Background:  Wound healing through second intention was prone to issues. As a result, there is a high need in veterinary medicine for medicines that hasten the healing of secondary wounds. These studies demonstrate the effect of autogenic, allogenic and heterogenic PRP on healing of wounds. Methods:  Six rabbits weighing (1.8-2.5 kg), blood samples were collected from the rabbits and goats. Skin markings of 1cm in diameter were made on dorsal midlines. These wounds were allocated into four groups, control, autogenic, allogenic and heterogenic PRP treated groups. Planimetric monitoring to determine the diameter (mm) and histologically were performed at 3,7,15, and 21 days after injury. Results:  Clinically, on day fifteen there were improvements in wound contraction in Auto and Allo PRP groups, better than control. There was slight improvement in the heteroPRP group. After 21 days of wounding, the Auto and AlloPRP group’s wounds were completely closed. Histopathologically, after 1 week, the AutoPRP and AlloPRP groups revealed scab formation. However, in the XenoPRP and control groups the thick scab covers the incision line. After 2 nd  week of post wounding, the two treated groups were nearly similar compared with the XenoPRP and control group including scab detachment. At the end of the 3 rd  week, The NS group revealed scab formation partially detached. While all treated showed a complete regeneration of the epidermis layer, newly formed hair follicles beneath the regenerated epidermis layer. Conclusion:  For the promotion of wound repair processes, autogenic additionally allogenicPRP therapy may be a straightforward, affordable, and successful option. Keywords: Platelet rich plasma; Rabbit; Skin; Wound