DefinePK

Abstract

Salmonella Typhi is the cause of typhoid fever. Together, Salmonella Typhi and Salmonella serovar Paratyphi A are the major agents of enteric fever. Typhoid fever affects millions of individuals each year in low-income nations. Human infection severity is determined by infectious doses and organism pathogenicity. Bacterial membrane and periplasm transporter proteins construct this barrier. These proteins remove antimicrobials, organic solvents, and toxic heavy metals from bacterial cells. Overexpression of the macAB-TolC genes induces macrolide resistance in Salmonella enterica. Salmonella pathogenicity is reduced in mice by macAB-TolC gene deletion. Due to its ability to expel structurally unrelated drugs. MdfA, a single cytoplasmic efflux protein, exports antibiotics when overexpressed.