DefinePK

Abstract

Mechanochemical activation by grinding appears to be the preferred method for the solid-state synthesis of the cyclodextrin inclusion complex because it is fast, highly effective, convenient, and versatile. It is also sustainable and eco-friendly since it uses no solvents. As a result of this review, we will highlight both the advantages and shortcomings of such an approach. Furthermore, we will review the current data in this area systematically. Several possible mechanisms have been illustrated to explain complex formation in the solid state as a result of grinding. We examined the process variables associated with each type of milling instrument applied, as well as the features of the resulting products. We also discussed the physio-chemical properties of the drug as well as cyclodextrin. As a result of the critical process parameters, a rational selection of conditions for the efficient preparation of inclusion complexes by grinding has been demonstrated, with the ultimate objective of increasing the use of this solvent-free process for preparing cyclodextrin inclusion complexes in solids.