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Abstract

Objective: To investigate the effects of Hepatitis B virus (HBV) infection status on the outcomes of pregnancy.
Methods: A retrospective study was conducted at Shunde Hospital of Southern Medical University (The First People’s Hospital of Shunde) from 1st January 2020 to 31st December2022.The study included 13,980 pregnant women, with 1,059 in the HBsAg-positive group (study group) and 12,921 in the HBsAg-negative group (control group). Pregnancy outcomes were compared between the control and study groups.
Results: Pregnant women who tested positive for HBsAg had higher rates of gestational diabetes mellitus (P=0.019; OR, 1.20; 95% CI, 1.03-1.40), intrahepatic cholestasis of pregnancy (P=0.019; OR, 1.85; 95% CI, 1.11-3.09) and preterm birth before 34 weeks (P=0.013; OR, 1.96; 95% CI, 1.15-3.34). The relationship between HBV infection status with gestational diabetes mellitus, intrahepatic cholestasis of pregnancy and preterm birth before 34 weeks was significant.
Conclusions: Pregnant women who tested positive for HBsAg faced a higher likelihood of developing gestational diabetes mellitus, intrahepatic cholestasis of pregnancy, and giving birth prematurely before 34 weeks. Further clarification is required regarding the influence of HBV infection on the outcomes of pregnancy.
doi: https://doi.org/10.12669/pjms.41.4.9578
How to cite this: Cai X, Huang S, Ma Z. HBV infection and pregnancy: Increased risks of gestational diabetes and preterm birth. Pak J Med Sci. 2025;41(4):952-957. doi: https://doi.org/10.12669/pjms.41.4.9578
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