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Abstract

Graves’ disease (GD) is an autoimmune disorder that manifests as goiter, weight loss, heat intolerance, and palpitations. It is rare in preschool-aged children (<5 years) and can lead to serious acute and long-term complications, including growth and development, if left undiagnosed.
We present the case of a four-year-old Hindu Asian girl from a low socioeconomic background who presented with progressive thyroid enlargement and symptoms of excessive sweating, heat intolerance, weight loss, diarrhea, fatigue, and palpitations over six months. Examination revealed symmetrical goiter, signs of thyrotoxicosis, bilateral exophthalmos, and raised blood pressure. Laboratory investigations confirmed Graves’ disease with suppressed TSH, elevated T3 and free T4, and persistently high TSH receptor antibodies (TRAb >40 IU/L). She was started on carbimazole and propranolol, resulting in clinical improvement; however, biochemical parameters, including TRAb levels, remain persistently elevated at eight months and suppressed TSH at 13 months, indicating a high risk of relapse. Long-term ATD therapy will be continued, with definitive treatment (RAI or thyroidectomy) considered if remission is not achieved after three years. This case underscores the challenges of managing Graves’ disease in young children and the need for prolonged monitoring and individualized treatment strategies.
doi: https://doi.org/10.12669/pjms.41.4.10689
How to cite this: Butt AT, Ayaz Ur Rehman, Ramzan S, Arif M. Graves’ disease in Children: A Case Report of Rare Occurrence. Pak J Med Sci. 2025;41(4):1253-1256. doi: https://doi.org/10.12669/pjms.41.4.10689
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.