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Synthesis of New Substituted Tetrazole and 4-Thiazolidinone from Schiff's Bases

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Title: Synthesis of New Substituted Tetrazole and 4-Thiazolidinone from Schiff's Bases

Authors: Amena Alyas Ahmed, Natiq Ghanim Ahmed, Ahmad Khuder Ahmad

Journal: Pakistan Journal of Scientific and Industrial Research (Series A: Physical Sciences)

HEC Recognition History
Category From To
Y 2023-07-01 2024-09-30
Y 2022-07-01 2023-06-30
Y 2021-07-01 2022-06-30
Y 2020-07-01 2021-06-30
Y 1900-01-01 2005-06-30

Publisher: Pakistan Council of Scientific and Industrial Research

Country: Pakistan

Year: 2020

Volume: 63

Issue: 1

Language: en

DOI: 10.52763/PJSIR.PHYS.SCI.63.1.2020.1.11

Keywords: tetrazolethiazolidinoneschiff's bases

Categories
Synthesis (183) Heterocyclic Chemistry (35) Chemical Synthesis (47) Organic Chemistry (862) Medicinal Chemistry (1249)

Abstract

 
The present work involved the synthesis of compound (1) (1-amino-4-methyl-6-phenyl pyrimidine- 2-(1H)-thione). This compound reacts with different aromatic aldehyde using glacial acetic acid as catalytic on absolute ethanol to give a new series of Schiff's bases (2-7). New thiazolidine-4-one were prepared from reactions of Schiff's bases (2,3,4,7) with thioglycolic acid in absolute ethanol giving compounds (8-11). Finally the preparation of new tetrazole derivatives (12-15) by reaction of Schiff's bases (2,3,4,7) with sodium azide in THF. The structure of the synthesized compounds are confirmed by I.R., 1H-NMR and 13C-NMR spectra and some physical  data.
 

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