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Abstract

Melasma, a chronic pigmentary disorder, is prevalent among women, particularly in South India, where environmental and cultural factors contribute to its occurrence. This study evaluates the efficacy and safety of oral tranexamic acid (TA) in treating melasma in patients at Sree Mookambika  Hospital, Kulasekharam, Kanyakumari, Tamil Nadu. Fifty patients were enrolled and administered 250 mg of TA twice daily for six months. Results showed significant improvement, with over 90% of participants experiencing pigmentation reduction. Mild side effects were reported in 10% of cases, and the recurrence rate was 12%. These findings highlight oral TA as an effective treatment option, with implications for tailored strategies in South Indian populations