DefinePK

Abstract

Background: We are the first to report on a safe dosage range via oral administration of whole plant Anogeissus pendula. According to the Organization for Economic Co-operation and Development (OECD) guidelines 423 and 407 respectively, acute and subacute oral toxicity studies were evaluated.
Material and Methods: Acute oral Toxicity was evaluated by oral administration of the extract as a single dosage (2000 and 5000 mg/kg b.w.) at 72 hours detrimental influences (including unwanted influence), death and behaviour have been observed up to 14 days. In the sub-acute oral studies, the extracts were administered orally at each of the three concentrations (500, 1000 and 2000 mg/kg b.w.) over 28 days, with changes observed during this recording period.
Result and Discussion: At a dose of 2000 mg/kg b.w. mild drowsiness and lethargy were reported in the treatment group extract; no behavioural change or symptoms at all. Administration of the liver extracts (2000 mg/kg b.w.) significantly enhanced the liver function indices.
Conclusion: The extract in the oral route did not show any sign of toxicity