DefinePK

Abstract

3,4-Dihydropyrimidinones are the most important heterocyclic compounds that are significant in the synthesis of nucleic acids. Dihydropyrimidinones have been produced by multi-component processes like the Biginelli reaction and the Hantzschdihydropyridine reaction.Due to extreme pharmacological action of dihydropyrimidinones, Biginelli reaction has been focused and derivatives are synthesized from past decades utilizing various catalysts and solvents to enhance more yield and decrease reaction time and to better pharmacological properties. In this review, we emphasize current advancements in this area, highlighting the recently developed DHPMs having better anti-inflammatory, antibacterial, antioxidant, antifungal, anticancer activities than the present standards