DefinePK

Abstract

Background: The increasing prevalence of E.coli causing UTIs and its resistance pattern has become a major global healthcare concern. ESBL-producing strains, in particular, pose a significant threat to public health and have complicated treatment approaches. Most reports on this issue are from urban areas, so there is a lack of data on antibiotic sensitivity patterns in semi-urban areas.
Aim and Objective: To Study the prevalence of extended-spectrum β-lactamases (ESBL) producing uropathogenic Escherichia coli (UPEC) and its antibiotic sensitivity pattern around the semi-urban region of Gurugram.
Material & Method: Urine samples were processed using the conventional method. As per the CLSI guidelines, confirmed E.coli isolates were tested for antibiotic resistance using the Kirby-Bauer disc diffusion method. All E.coli isolates were subjected to ESBL HiCrome agar and DDST using combination drugs as per the CLSI guidelines for the phenotypic detection.
Results: Out of 485 samples, 256 (52.78%) ESBL E.coli were observed. The antibiogram of the ESBL-producing isolates showed higher resistance rates to cephalosporins compared to non-cephalosporin antibiotics. There was a low degree of resistance observed against aminoglycosides and carbapenem.