DefinePK

Abstract

Background: Non-Hodgkin Lymphoma (NHL) is a malignant neoplasm originating from lymphoid tissue, especially lymph nodes. The incidence of NHL is 3% of all tumors in the head and neck area, 85% of malignant lymphoma are extranodal NHL, and 1% of primary tumors originate from the larynx. Standard management of NHL is chemotherapy or combination with radiotherapy. Purpose: To report two rare cases of laryngeal NHL, the types of regimens, and their responses to chemotherapy. Case Reports: Two cases of laryngeal NHL. The first case was a 58-year-old woman who gave a complete chemotherapy response; the second was a 17-year-old boy who gave a complete chemotherapy response. Treatment: Chemotherapy with six cycles of CHOP regimen (Cyclophosphamide, Oncovin, Doxorubicin, and Prednisone) for the first case and 16 cycles of COMP regimen (Cyclophosphamide, Vincristine, Methotrexate and Prednisone) for the second case. Conclusion: Six cycles of chemotherapy using the CHOP regimen in adult patients and 16 cycles with the COMP regimen in pediatric patients gave a complete chemotherapy response.