DefinePK

Abstract

This study explores the formulation and characterization of nanofibers incorporating Pravastatin, Aloe vera juice, and Onion oil for potential wound healing applications. The organoleptic properties, solubility, UV, FTIR, and DSC analyses confirmed the compatibility of the drug and excipients, with no significant interactions observed. Phytochemical screening revealed active bioactive compounds in Aloe vera and Onion oil, highlighting their therapeutic potential. Optimized nanofiber formulations exhibited excellent drug content, entrapment efficiency, and sustained drug release. Stability studies over three months showed minimal variation in drug properties. The in vivo burn wound healing study demonstrated a significant enhancement in healing (84.17%) with nanofiber treatment compared to the control group (44.32%). Histopathological evaluation showed normal skin architecture with mild epithelial changes in treated samples, further supporting the promising therapeutic potential of these nanofiber formulations for effective wound healing.