DefinePK

Abstract

Hyperlipidemia is characterized by an  abnormal blood lipid level. the most  prevalent kind of dyslipidemia, hyperlipidemia (hl), it is marked by  increasing levels of TG, LDL-C, and peripheral blood total cholesterol (TC), along with a decrease in HDL levels The aim of the study was to determination how Cephalexin affected on the normal microbiota that could affect Rosuvastatin pharmacokinetics in rabbits with induced hyperlipidemia. Ten  rabbits were divided into two  groups  ware given  a diet containing 1.3% cholesterol and  3% saturated fat  for 40 days. and the experiment was divided into groups: G1 hyperlipidemia rabbits treated with Rosuvastatin  orally 0.86 mg/kg for 7  days. G2 hyperlipidemia rabbits treated with Cephalexin ( orally) after two hours are given Rosuvastatin orally 0.86 mg/kg for 7  days. using a 3 ml plastic syringe, 1 ml of blood was drawn from each animal in each group's femoral vein, heart, jugular vein, and marginal ear vein. At 0.10, 0.30, 1, 2, 4, 6, 8, and 24 hours after treatment, the samples were taken. The amount of Rosuvastatin in the plasma was ascertained using HPLC (high-performance liquid chromatography).The results showed that co-administration of Rosuvastatin, Half-Life (T1/2): G1 has the longest half-life, while G2 have shorter half-lives. Cmax (maximum concentration): G1 shows the highest Cmax, with G2 having the lowest. Tmax (time to reach maximum concentration): G2 has the longest Tmax, indicating a delayed peak concentration compared to G1. Vd (volume of distribution): G1 has the highest Vd, suggesting a wider distribution the drug in the body. CL (clearance): G2 shows the highest clearance rate, indicating faster elimination  drug. area under the curve, or AUC 0-inf: G1 has the largest AUC, indicating increased drug exposure with time. There is a significant difference between the means with different letters in the same row (P<0.05), indicating statistical differences in the pharmacokinetic parameters among the groups. In conclusion, findings provide insights into the pharmacokinetic behavior of Rosuvastatin in hyperlipidemic rabbits and suggest potential interactions when combined with antibiotics.