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Abstract

Background: An elevation in serum bilirubin levels without significant changes in liver enzymes or other biochemical markers, presents a unique diagnostic challenge. In evaluating these patients, liver enzyme levels play a key role in differentiating between hepatic and non-hepatic causes of hyperbilirubinemia.
Methodology: A cross-sectional study was conducted on 200 patients with isolated hyperbilirubinemia at Raipur Institute of Medical Science & Hospital, Chhattisgarh, over two years. Patients aged 18 and above were included. Data were analysed using SPSS version 20, with descriptive statistics (mean & SD), and a p-value < 0.05 considered significant.
Result: The study included 200 subjects (63% female, 37% male) with elevated bilirubin levels, with a mean age of 34.23 ± 15.56 years. Total bilirubin was 15.34 ± 8.54 mg/dl. Significant differences were found between genders for direct bilirubin, ALT, creatinine, and urea.
Conclusion: Assessing bilirubin, liver enzymes, and electrolytes in isolated hyperbilirubinemia aids in differentiating benign conditions from more serious ones.