DefinePK

Abstract

Parkinson’s disease is a neurological ailment that progresses over time and affects millions of people worldwide. It is characterized by a complex combination of motor and non-motor symptoms. The study focused on bioactive components derived from Eucalyptus citriodora leaf extracts through qualitative and quantitative examination of antioxidant scavenging activity, along with in vitro cytotoxicity assessment and antimicrobial activity.  The findings of the study revealed the IC50 values for the plant extract in various antioxidant assays like Nitric oxide scavenging and ferric reducing power showed an IC50 of 85.87µg/ml, Hydrogen peroxide scavenging assay exhibited an IC50 of 206 µg/ml. Additionally, the Phosphomolybdenum assay indicated a plant extract content of 21.45µg/ml. To assess the relative amounts of different components, TLC chromatography was conducted, and the Eucalyptus extract was compared with quercetin, revealing a retention factor (Rf) of 2.33.
The cytotoxic assay to determine the percentage of cell viability in isolated liver cells also exhibited maximum flavonoid compared to alkaloids compound. The IC50 value was identified as 147ug/ml. According to the findings, Eucalyptus citriodora has a high potential for antioxidants, which are molecules that are thought to be physiologically active.