DefinePK

Abstract

Bisphosphonates are highly efficient antiresorptive drugs used to treat diseases with increased osteoclast activity such as cancer-related conditions, osteoporosis, multiple myeloma, Paget disease, osteosclerosis, and fibrous dysplasia. Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is defined as a current or previous treatment with BPs that leads to an exposed bone or bone that can be probe through a fistula in the maxillofacial region that does not heal within eight weeks.