DefinePK

Abstract

Background: The most common endocrine malignancy in the world is papillary thyroid carcinoma, with rising numbers worldwide. The prognosis of this tumor is determined by age, size, local invasion and metastasis. Cell proliferation determined tumor size, where cancer stem cell such as CD44 becomes the main driver. Numbers of pathways will affect cell proliferation, CD44 could impact protein such as cyclin dependent kinase 4 (CDK4) which will affect cell cycle, causing increased proliferation which in turn, altering disease progression.
Objective: To analyze correlation between CD44 and CDK4 expression in various T stages of papillary thyroid carcinoma
Methods: This research is observational analytical cross-sectional research. Samples of paraffin blocks from patients diagnosed with papillary thyroid carcinoma from January 2019 to December 20202, who underwent lobectomy, isthmolobectomy and thyroidectomy. Samples then were categorized into groups according to their pathological T (pT) stage. Immunohistochemistry staining was done using CD44 and CDK4 antibodies. Differences of expression across different pT stage groups was done using statistics.
Results and Discussion: No differences in CD44 expression in various pT stage of papillary thyroid carcinoma (p=0.335), no correlation found (p=0.703). No differences in CDK4 expression in various pT stage of papillary thyroid carcinoma (p=0.904), no correlation found (p=0.752). Positive correlation was found between CD44 and CDK4 expression (p=0.0000849, r=0.518).
Conclusion: Various CD44 and CDK4 expression was found in various pT stage of papillary thyroid carcinoma, with positive correlation between CD44 and CDK4.