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Abstract

This systematic review aims to elucidate the chemical makeup of Larsen embalming fluid and its toxicological effects in anatomy laboratories, specifically with its use in newborn rat surgical preparation. The prevalent use of formaldehyde-based solutions for cadaver preservation effectively inhibits decay but presents considerable health risks, including respiratory inflammation, tissue discoloration, and potential carcinogenicity. The revised Larsen solution diminishes formaldehyde emissions by integrating chloral hydrate, glycerol, and certain inorganic salts, which assist in preserving natural tissue coloration, ensuring elasticity, and enhancing stability while reducing chemical hazards. These features are especially pertinent in the preparation of neonatal rat specimens for surgical training and anatomical research, where tissue integrity and minimized toxic exposure are essential. A thorough literature analysis was performed utilizing peer-reviewed academic databases such as PubMed, Scopus, the Web of Science, Google Scholar, and ScienceDirect to examine intricate chemical compositions and toxicological evaluations. This review emphasizes the efficacy and safety of this embalming formulation, providing insights into its prospective advantages for newborn surgical research, occupational health, and environmental preservation.