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Abstract

Background: Prediabetes is a critical condition that increases the risk of progressing to Type 2 diabetes and cardiovascular diseases. An elevated waist-to-hip ratio (WHR), is a key factor in the development of metabolic disturbances, including dyslipidemia and impaired glucose metabolism.
Methodology: A case-control study was conducted with 120 subjects (ages 30-65) consist of 60 prediabetic and 60 control participants, based on ADA criteria. Lipid parameters and glucose were measured using the EM-200 analyzer. Independent t-tests were applied to compare biochemical markers between the two groups, and Spearman correlation tests applied to find out association of waist-to-hip ratio with lipid parameters and glucose levels. A p-value < 0.05 was considered statistically significant.
Result: The study included 120 subjects (60 prediabetic, 60 controls) with 63% males and 37% females, aged 41.23 ± 15.56 years. The average fasting plasma glucose was 110.1 ± 44.8 mg/dl. A significant correlation was found between waist-to-hip ratio (WHR) and HDL (r=0.28, p=0.001).
Conclusion: Higher WHR, indicating more abdominal fat, is strongly linked to higher blood glucose and poor lipid profiles, including increased triglycerides, low HDL, and high LDL cholesterol.