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Abstract

Some phytochemicals play a major role in protecting neuronal health.  Leucas aspera exhibits beneficial effects in supporting neuroprotective activities. The major role of Leucas aspera extract was studied for antioxidant and antimicrobial activities. Phenols and flavonoids derived from the plant help in the scavenging activity of free radical ions by lowering the stress involved in increasing the levels of oxidative ions in the body and shielding cells from internal harm. This study focuses on evaluating the effects of Leucas aspera for its antioxidant activity by performing DPPH (2, 2-diphenyl-1-picrylhydrazyl), Nitrite assay using Nitric Oxide, and (2, 2'-azinobis-3-ethylbenzothiazoline-6sulphonic acid) ABTS assay. The obtained nitric oxide IC50 value was 89.60 (µg/ml). In addition, the Leucas aspera extract zone of inhibition was measured and antibacterial activity of the plant extract concerning Bacillus subtilis (0.469 µg/ml) Staphylococcus aureus (10 µg/ml), Klebsiella pneumoniae (9 µg/ml), E. coli (8.25 µg/ml), Candida albicans (7.5 µg/ml), Penicillium chrysogenum (8.0 µg/ml), Aspergillus niger (8.5 µg/ml). This suggests that polyphenols and flavonoids derived from Leucas aspera contain precursors that are potential metabolites responsible for the cure and management of the progress of neurodegenerative diseases. Leucas aspera-derived compounds from the chromatography technique are beneficial in analyzing bioactive compounds towards the neurodegenerative disorder.