DefinePK

Abstract

Background: Tuberculosis is an ancient scourge. It has plagued humankind throughout known history and human pre-history. Mycobacterium tuberculosis have killed more persons than any other microbial pathogen [1]. Although the thorax is most frequently involved, tuberculosis may involve any of a number of organ systems like the respiratory, cardiac, central nervous system, musculoskeletal, gastrointestinal, and genitourinary systems and timely diagnosis of the disease is paramount, since delayed treatment is associated with severe morbidity [2].Thus the antibacterial properties of Rifamycin, 8-(morpholinomethyl)-, a molecule with the chemical formula C42H56N2O13 and a molecular weight of 796.9 g/mol, are investigated in this work.
Methodology: Rifamycin, 8-(morpholinomethyl)- was obtained in solid powder form and chemically synthesized. It was then examined using the Hexa disc method for Mycobacterium tuberculosis. When the pathogen was inoculated over sterilized agar plates, different doses of Rifamycin, 8-(morpholinomethyl)- were administered. The inhibitory zones that evolved around the wells were measured in diameter. The outcome was contrasted with a positive control [3].
Results and Discussion: The study found that Rifamycin, 8-(morpholinomethyl)- had substantial antibiotic action against Mycobacterium , with inhibitory zones growing in size with increasing concentrations. The findings suggest that the chemical compound can be used in the treatment of tuberculosis.
Conclusion:This study highlights Rifamycin, 8-(morpholinomethyl)-'s potent antibacterial qualities, which make it a viable option for treating tuberculosis. The compound's metabolites outperform its positive control thus serve a significant part in their efficacy. This study creates opportunities for further research and antitubercular application development.