DefinePK

Abstract

Background: Type 2 diabetes mellitus (T2DM) and depression are among the most prevalent chronic conditions globally, frequently co-occurring and compounding one another’s severity and management complexity. Their bidirectional relationship adversely impacts treatment adherence, glycemic control, and overall quality of life. Primary care settings, as the frontline of healthcare, offer an optimal platform for integrated management, yet conventional approaches often remain fragmented.
Objective: This narrative review aims to explore the current landscape of integrated care models for the concurrent management of T2DM and depression in primary care, highlighting their effectiveness, challenges, and future directions.
Main Discussion Points: The review synthesizes findings from recent literature emphasizing the value of multidisciplinary collaboration, including the use of case managers, mental health professionals, and primary care physicians. Integrated care models such as CIC-PDD demonstrate improvements in both metabolic and mental health outcomes, self-care behaviors, and patient satisfaction. Key themes include clinical efficacy, patient-centered care, health system efficiency, cultural adaptability, and cost-effectiveness. Limitations noted across studies include methodological inconsistencies, short follow-up durations, and challenges in scalability and generalizability.
Conclusion: Integrated care for T2DM and depression in primary settings shows strong clinical promise, with evidence supporting improved patient outcomes and system-level efficiencies. However, further high-quality, long-term, and diverse studies are essential to establish standardized, sustainable, and globally applicable models.