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Abstract

Hepatitis B and C virus (HBV, HCV) remains a global health burden, often leading to progressive liver damage including cirrhosis and hepatocellular carcinoma. Liver function tests (LFTs), including ALT, AST, ALP, bilirubin, and albumin, serve as non-invasive indicators of hepatic inflammation, hepatocellular injury, and synthetic dysfunction. The aim of this study was to determine the correlation of hepatitis B and C infection with abnormalities in liver function tests among patients at Sir Ganga Ram Hospital, Lahore, Pakistan. A cross-sectional study was conducted at the pathology and clinical biochemistry departments. A total of 323 HBV (161) and HCV (162) positive patients were included in the study. Venous blood samples were collected under aseptic conditions and analyzed for liver function parameters. Parameters levels were measured using automated chemistry analyzers Mindray BS-200 and ROCHE COBAS C311. Among 161 HBV-positive patients, ALT, AST and ALP was recorded as 45.2±18.3, 50.5±21.4 and 110.7±34.2 respectively. Among 162 HCV-positive patients, ALT, AST and ALP was recorded as 62.7±22.7, 79.8±24.3 and 129.6±39.1 respectively. HCV infection significantly alters liver enzyme more as compared to HBV. These findings support the importance of regular liver function monitoring to ensure timely diagnosis and management of hepatic complications.