DefinePK

Abstract

Background: Smoking-induced Chronic obstructive pulmonary disease (COPD) is a chronic lung condition causing airflow obstruction and inflammation, leading to symptoms like breathlessness and fatigue. While expiratory issues are well-studied, the impact of inspiratory function on symptoms is less understood.
Objective: To measure inspiratory volumes and capacities, as well to establish a relationship between these variables and clinical characteristics of COPD.
Study type, settings & duration: This cross-sectional study performed at Mayo Hospital, Lahore from March to October 2022.
Methodology: A total of 320 samples were divided into two groups, i.e., COPD and healthy control. Spirometry was performed to correlate lung function with serum SPD levels. We developed a regression model to assess the relative contribution of each variable to the inspiratory functions. Data was analyzed by using Statistical Package for Social Sciences (SPSS) version 16. Continuous metric variables will be described as mean ±SD.
Results: Of the 320 samples, 192 were from males (60%) and 128 (40%) were from females. Mean age of individuals in study was 45±6.11 year. The level of peak inspiratory flow rates among COPD patients (2.15±0.98) were lower (p =0.000) as compared to healthy control (4.06±1.33). Likewise, PIF% predicted was lowered (p =0.000) in COPD (26.91±11.90) as compared to healthy controls (45.67±16.17). Forced inspiratory vital capacity was lowered (p =0.000) among COPD (1.99±0.80) as compared with the control (3.40±0.87) group.
Conclusion: The study suggests that inspiratory volumes and capacities are crucial for hospital admission, diagnosis, management, and staging of COPD. These metrics are significantly lower ........