DefinePK

Abstract

Objective: To determine the correlation between inflammatory markers (fecal calprotectin and CRP) and Simple Endoscopic Score for Crohn's Disease (SES-CD) in patients with Crohn's disease. Study Design: Cross-sectional study. Setting: Department of Medicine, Liaquat University of Medical and Health Sciences. Period: 24th August 2024 to 24th February 2025. Methods: Thirty-three patients with endoscopically diagnosed Crohn's disease were enrolled. Blood samples for CRP and first-morning stool samples for fecal calprotectin were collected. SES-CD was calculated during endoscopic evaluation. Demographic and clinical data were recorded using standardized proformas. Spearman's correlation coefficient was used to assess relationships between variables. Results: The study included 33 patients with a median age of 44.00 years (IQR: 34.00-52.50) and mean BMI of 25.86 ± 2.30. The median SES-CD score was 8.00 (IQR: 6.00-13.00), and mean CRP level was 14.00 ± 6.48 mg/L. Spearman correlation analysis revealed strong positive correlations between SES-CD and both fecal calprotectin (ρ = 0.994, p < 0.001) and CRP levels (ρ = 0.993, p < 0.001). A significant correlation was also found between SES-CD and BMI (ρ = 0.882, p < 0.001). No significant correlations were observed between SES-CD and age (ρ = 0.048, p = 0.791), gender (ρ = -0.102, p = 0.571), or disease duration (ρ = -0.017, p = 0.925). Conclusion: Both fecal calprotectin and CRP demonstrated strong correlations with endoscopic disease activity in Crohn's disease, suggesting their potential utility as reliable non-invasive biomarkers for monitoring disease severity and guiding treatment decisions.