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Abstract

Objective: To investigate clinical efficacy of novel biogenically fabricated titania nanoparticles enriched mouth wash in treating dentin sensitivity of patients.
Methods: Tripple blinded randomized clinical trial was conducted at School of Dentistry Islamabad from 6th June 2024 to 6th December 2024 incorporating participants (n = 260) with Group-A (n = 130) and Group-B (n = 130). After attaining informed consent and randomization, Visual Analog Scoring system (VAS Value) was induced to check the Dentin hypersensitivity (DH) of the participants at baseline, after one month and three months follow up. Group-A was given Conventional Mouth wash and Group-B was given Novel-Nanoparticles (Nps) Mouth Wash for total three months to treat DH. The primary outcome was calculated as mean VAS Values for both Groups-A and B after one month and three months. Mann-Whitney-U Test was used for comparing DH between these two groups.
Results: According to trial results, significant difference was obtained between Group -A that used Conventional Mouth wash and Group-B that used Novel- Nps Mouth wash after one month (p = 0.001) and three months (p = 0.002).
Conclusion: DH declination was more prominent in patients that used Novel- Nps Mouth wash with nanoparticles in comparison to participants that used Conventional Mouth wash without any nanoparticles. This concludes that inclusion of biogenically fabricated titania nanoparticles in clinical dentistry could be beneficial in resolving Dentin Hypersensitivity.
ClinicalTrials.gov ID: NCT06790953 at U.S. Protocol Registration and Result System.
doi: https://doi.org/10.12669/pjms.41.6.11856
How to cite this: Mansoor A, Mansoor E, Hussain K, Khan S. Clinical efficacy of novel biogenically fabricated titania nanoparticles enriched mouth wash in treating the tooth dentine hypersensitivity: A randomized clinical trial. Pak J Med Sci. 2025;41(6):1743-1748.  doi: https://doi.org/10.12669/pjms.41.6.11856
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