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Abstract

Objective: The study assessed differences in the thyroglobulin antibody and thyroid peroxidase antibody between euthyroid Type-I and Type-II diabetes mellitus (DM) and control groups not using thyroid medication.
Methods: This was a cross-sectional study. People with Type-I and Type-II diabetes and a control group aged between 18 and 80 years were enrolled at the diabetes and internal medicine outpatient clinic of Istanbul Haydarpaşa Numune Training and Research Hospital between 2020-2023. Data analysis was performed on 103 participants with Type-I DM, 110 with Type-II DM, and 110 control subjects, all randomly selected. Anti-thyroglobulin antibody (anti-TG), anti-thyroperoxidase antibody (anti-TPO), thyroid-stimulating hormone (TSH), fasting blood glucose (FBG), hemoglobin A1c, (HbA1c) and blood creatinine levels were recorded for analysis.
Results: In the study, anti-TG and anti-TPO levels were higher in Type-I DM patients than in the control and Type-II DM groups. This elevation was statistically significant in women with Type-I DM compared to women patients in other groups. In this study, thyroid antibody levels in patients with Type-II DM were not significantly higher than those in the control group.
Conclusions: This study highlights the importance of regular assessment of thyroid function and antibodies in women diagnosed with Type-I DM, but not necessarily in those with Type-II DM without thyroid disease.
doi: https://doi.org/10.12669/pjms.41.7.11918
How to cite this: Dayan A, Yonak AK. Assessment of Serum Thyroid Antibody Levels in Patients with Type-I and Type-II Diabetes without Thyroid Disease. Pak J Med Sci. 2025;41(7):1996-2002. doi: https://doi.org/10.12669/pjms.41.7.11918
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