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The Peptide Paradox in Pharmacology of Obesity

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Title: The Peptide Paradox in Pharmacology of Obesity

Authors: Sanjay Kalra, Amandeep Singh, Nitin Kapoor

Journal: Journal of Pakistan Medical Association

HEC Recognition History
Category From To
Y 2024-10-01 2025-12-31
X 2023-07-01 2024-09-30
X 2022-07-01 2023-06-30
X 2021-07-01 2022-06-30
X 2020-07-01 2021-06-30
W 2012-07-01 2020-06-30
X 2011-05-13 2012-06-30
Y 1900-01-01 2005-06-30

Publisher: Pakistan Medical Association.

Country: Pakistan

Year: 2025

Volume: 75

Issue: 7

Language: en

DOI: 10.47391/JPMA.25-53

Categories
Obesity (578) Metabolism (698) Pharmacology (22872) Endocrinology (11489) Peptides (8)

Abstract

Peptide biology is a fascinating subject, and peptidepharmacology even more so. Peptides have multiple bodilyfunctions, including their work as hormones and metabolicmodulators. However, certain pharmacodynamic andkinetic properties of peptides used in obesity result inparadoxical outcomes. It is helpful for the treating clinicianto be aware of these peptide paradoxes, which not onlyhelp in understanding the rationale of using these drugsbut also help to explain their differences in clinical actions.
Keywords: biological paradox, dual agonists, GIP receptoragonists, GLP receptor agonists, glucagon agonists,peptide biology, semaglutide, tirzepatide, triple agonists,

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