DefinePK

Abstract

Abstract: Diabetes, a chronic disease characterised by hyperglycaemia, affects millions worldwide. Despite various treatments, weight management may affect the complications of disease. Weight gain and diabetes have been researched for decades. This review examined the relationship between weight loss and HbA1c level improvements among diabetes, the effects of weight loss on other diabetes outcomes, the factors of individual response to weight management, long-term HbA1c control, and the conditions under which weight reduction may be effective. Hence, diabetes, weight change, HbA1c, and other MeSH terms and keywords were searched in PubMed, Medline, EMBASE, Cochrane Library, Scopus, and CINAHL. We cross-referenced relevant articles' reference lists and intensively searched grey literature including conference proceedings, preprints, government reports, and institutional research papers. This research reveals that diabetics' HbA1c control improves with sustained weight loss. Despite individual variation and restrictions, the findings underline the need of weight management in diabetes therapy. The findings emphasis the need of including weight-management strategies into comprehensive diabetes treatment plans, while acknowledging both individual differences and constraints. Subsequent studies should include these characteristics and modify the suggestions appropriately, while also evaluating the long-term outcomes and determining effective strategies for achieving weight reduction in individuals with diabetes.