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Abstract

Aggressive behavior holds adverse responses toward conditions. Aggression is a human and animal behavioral phenotype that is deeply concerned with genetics and environmental factors. Literature states the MAO-A (monoamine oxidase A) gene is responsible for aggression and violence. Monoamine Oxidase-A gene translates the MAOA enzyme present in mitochondria, which has a role in degrading neurotransmitters such as dopamine, serotonin, and nor-adrenaline. A high level of MAOA leads to several abnormalities of depression, anxiety, etc. while a low level of MAOA can lead to criminal and aggression disorders. The VNTR (Variable number tandem Repeat) polymorphism was detected in MAOA gene. This Polymorphism are highly found in the Asian and African populations. This study has big importance for the defense agencies of the area and has broad forensic value.
Objectives. The main focus of this study is to investigate aggressive individuals and find their association with MAOA gene polymorphism.
Methods. Aggressive patients were determined using a questionnaire. Total of 128 buccal swab samples was extracted from the patients. For identifying polymorphism conventional PCR was perform.
Results. All the individuals’ behavior was assessed and found 48 individuals with high aggression, 48 with very low aggression and 32 as normal. We genotyped 128 individuals and successfully find out 3 different types of polymorphism 321bp, 351bp, and 381bp. In comparison with other populations, we have 321bp size as more repetitive. Chi Square test show the linkage (P value 0.00) of MAOA gene polymorphism and behavior variation.