DefinePK

Abstract

The role of lipid metabolism in the development and progression of coronary artery disease (CAD) is well-documented, but its precise impact on CAD severity and clinical interventions remains an area of active research. This study aimed to investigate the relationship between lipid profile abnormalities—specifically low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides—and CAD severity, while evaluating the effect of lipid-lowering intervention on lipid parameters. A total of 200 CAD patients were enrolled and stratified by disease severity (mild, moderate, and severe). Clinical and demographic data were collected, alongside lipid profiles, including LDL-C, HDL-C, triglycerides, and total cholesterol. Research data showed that LDL-C played a critical role in atherosclerosis as its values rose while CAD became more severe yet declined during treatment periods.  The past research data illustrated a positive relationship between triglyceride levels and CAD severity.  Research on lipid-lowering drugs across three months confirmed positive effects on decreased LDL-C and triglycerides combined with elevated HDL-C levels thus highlighting potential drug treatments to stop CAD progression.  The regression analysis results confirmed that LDL-C together with triglycerides and HDL-C serve as vital risk determinants for CAD.  Subgroup evaluation data showed diabetes patients combined with hypertension patients had higher LDL-C and triglyceride levels thus pointing to the significance of personalized lipid therapy methods for high-risk patient groups.  The findings show that cholesterol management techniques offer promising therapeutic benefits and show the importance of accomplishing early lipid evaluation and timely CAR treatment interventions.  Future studies should identify basic lipid metabolism processes in coronary artery disease patients while conducting extended assessments of selected therapeutic methods..