DefinePK

Abstract

Background:  Purple passion fruit seed extract (PPFSE) is rich in antioxidant and photoprotective and therefore has potential as alternative treatment for melasma
Objective: This study aim to evaluate therapeutic effects of 4% and 10% PPFSE cream to 4% hydroquinone (HQ) cream for epidermal type melasma.
Methods: A randomized double-blind clinical trial was conducted. The study participants were divided into three groups, PPFSE cream 4%, 10% group and HQ cream 4% group. Severity of melasma was assessed with modified melasma area severity index (mMASI), melanin index (MI) with Mexameter® and Mark-Vu® skin analysis and quality of life index for melasma with melasQol at baseline, week 4, 8, and 12  for each arm
Results: A total of 38 participants were included. There was a significant reduction in mMASI, MI, and melasQol scores before and after 12 weeks of treatment across all groups (p=0.000). The difference between mMASI and melanin index before and after 12 weeks of treatment was lower in the PPFSE 4% than the HQ 4% (p<0.05)
Conclusion: PPFSE cream 10% can be a viable option for treatment of epidermal type melasma