DefinePK

Abstract

Easily ruptured superficial vesicles or bullae are a hallmark of the chronic autoimmune illness pemphigus. The two primary subtypes of pemphigus are pemphigus vulgaris (PV) and pemphigus foliaceus (PF), which can infrequently coexist or even change from one to the other. Changes in the autoantibody profile for desmoglein that are both qualitative and quantitative may help to explain this process. We describe a case of PF and PV present at the same time on a 73-year-old woman from clinical findings revealed multiple flaccid bullae on the face, neck, left and right arm and thigh, stomach, and back. Erosions, excoriations, and crusts were present. Nikolsky's sign was positive. Her histopathological examination showed subcorneal and suprabasal acantholysis. Basal cells were formed in a “row of tombstones” appearance.