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Abstract

Objective: To assess the comparative effect of high protein milk feeding on routine blood parameters and nutritional status in ovarian cancer patients undergoing chemotherapy
Method: This study was a single-blind randomized controlled clinical trial involving 96 samples divided into 2 groups, including interventional group (n = 48) and control group (n = 48). The intervention group patients received additional nutrition in the form of high-protein and high-calorie milk and vitamin B complex supplementation.
Result: In the control group, there was a significant decrease in BMI (p=<0.001),karnofsky scale (p<0.001), platelets (p=0.003), and hemoglobin (p=0.030) and an increase in PG-SGA (p=<0.001) and NLR (p=<0.001). In the nutritional intervention group, there was a significant increase in karnofsky score (p<0.001) and decrease in PG-SGA (p=0.001), BMI (P<0.001) and platelet (p=0.018) values after undergoing chemotherapy. Comparison between groups showed that the nutritional intervention group had significantly lower values of PG-SGA, leukocytes, platelets, NLR, and PLR and significantly higher BMI and karnofsky score than the control group after undergoing a series of chemotherapy.
Conclusion: The high protein milk intervention can improve nutritional status and inflammatory parameters in ovarian cancer patients undergoing chemotherapy.