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Abstract

Background:
Non-healing ulcers represent a significant public health concern, leading to considerable disability and reduced quality of life. Autologous platelet-rich fibrin (PRF) has emerged as a promising, biologically active scaffold that promotes wound healing.
Objective:
To evaluate the efficacy of PRF in the treatment of chronic, non-healing leg ulcers.
Methods:
This prospective study included 10 patients aged over 18 years with chronic leg ulcers (>8 weeks' duration) unresponsive to conventional therapies. Exclusion criteria included bleeding disorders, pregnancy, lactation, anticoagulant use, and deep ulcers with exposed structures. PRF was derived from the patient’s blood and applied once weekly for a maximum of five weeks or until complete healing. Ulcer dimensions were recorded at each visit, and serial photographs were taken.
Results:
The average age of the patients was 41.2 years, with a male-to-female ratio of 2:1. The mean ulcer area measured 7.22 cm², and the average duration of ulcers before treatment was 5.1 months. Underlying causes included Hansen’s disease (n=4), diabetic foot ulcers (n=3), venous ulcers (n=2), and one case of a neuropathic ulcer. Complete healing was achieved in all cases, with no adverse events or recurrence noted during the 3-month follow-up period.
Conclusion:
PRF is a safe, effective, and cost-efficient treatment for non-healing leg ulcers, demonstrating significant potential for wider clinical use.