DefinePK

Abstract

Background: Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit. Chemical peels such as glycolic acid (GA) and salicylic acid (SA) are popular, safe, and non-invasive treatment modalities.
Objective: To compare the clinical efficacy and tolerability of high-strength 70% GA and 30% SA peels in the management of mild to moderate acne vulgaris.
Methods: A prospective study was conducted from May 2024 to October 2024. Forty patients with mild to moderate acne (as per Global Acne Grading System - GAGS) were randomized into two groups. Group A received 70% GA peel, and Group B received 30% SA peel, with treatments administered at an interval of 2 weeks for a total of 6 sessions (12 weeks). Outcome was assessed by GAGS score and clinical photography.
Results: Group B (SA) demonstrated faster and greater GAGS score reduction (65%) compared to Group A (GA, 46%). Both treatments were well tolerated, with minor adverse events in <15% of patients.
Conclusion: Both peels were effective; however, 30% SA peel showed superior clinical response and earlier onset of action.