DefinePK

Abstract

Background: Keloids are fibroproliferative disorders resulting from an aberrant wound-healing process. They are notorious for their resistance to conventional treatments and their tendency to recur. While intralesional corticosteroids remain a mainstay in treatment, newer combination techniques are being investigated to enhance outcomes.
Objective: To compare the therapeutic efficacy and safety of intralesional triamcinolone acetonide (TAC) monotherapy versus modified intralesional radiofrequency (mRF) with TAC injection in patients with keloids.
Materials and Methods: A prospective comparative study was conducted between 1st May 2024 to 31st October 2024. Thirty patients with keloids were enrolled and randomized into two equal groups: Group A received intralesional TAC (40 mg/mL), and Group B underwent a modified intralesional RF technique with TAC. Four treatment sessions were conducted at 4-week intervals, with outcomes evaluated by Patient and Observer Scar Assessment Scale (POSAS).
Results: Group B exhibited a greater reduction in POSAS scores 71.53% compared to Group A (65.32%). Group B also showed a more significant reduction in keloid size and technique was well tolerated in treatment of keloids.
Conclusion: Modified intralesional RF with TAC is a superior modality to TAC alone for treating keloids, offering better efficacy and safety with minimal complications.