DefinePK

Abstract

Cancer remains a leading cause of morbidity and mortality worldwide. Oridonin, a tetracyclic diterpenoid from Rabdosia rubescens, has gained significant research interest due to its neuroprotective, anti-inflammatory, and anticancer properties. Structural modifications have led to derivatives with enhanced pharmacological activity. While drug resistance remains a major challenge in chemotherapy, oridonin has demonstrated the ability to overcome resistance through multiple mechanisms, making it a promising candidate for cancer treatment.