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Abstract

Background: Polycystic ovary syndrome (PCOS) is one of the common endocrine disorders denoting an imbalance between hormone secretions and menstrual abnormalities with insulin resistance. Recently, it has been implicated that Vitamin D deficiency may contribute in some manner to the pathogenesis of PCOS. This study aims to assess the impact of Vitamin D supplementation on the hormonal profile, insulin sensitivity, and clinical manifestations in women with PCOS.
Methods: A prospective interventional study was carried out on 100 patients with PCOS divided into two groups: 1) One group received 60,000 IU/week of Vitamin D3 along with lifestyle modification; 2) the control group, namely, lifestyle modification alone. Clinical, hormonal, and metabolic parameters were measured at baseline and at the end of 12 weeks.
Results: The Vitamin D group showed very good improvement in menstrual disturbances, acne, hirsutism, mood swings, and weight status. Hormone levels were fully reversed, and insulin resistance was reduced significantly. The control group showed minimal changes.
Conclusion: Vitamin D supplementation is both efficacious and safe to restore the hormonal and metabolic profile in PCOS, hence can be envisaged as adjuvant therapy.