DefinePK

Abstract

Battling localized bacterial infections requires advanced drug delivery. This research introduces a Nanosponges-based nanogel designed for controlled bacitracin release, targeting gram-positive pathogens. Motivated by the need for enhanced therapy and reduced dosing, this novel system aims to revolutionize localized antibiotic treatment. Nanosponges, encapsulating bacitracin, were created using emulsion solvent diffusion method, optimized via  3² factorial design. These were incorporated into a nanogel using gelling agents. Evaluations included particle size, FTIR, in vitro release, entrapment efficiency, SEM, and XRD. Specific formulations showed promising attributes: controlled drug release, efficient entrapment, and suitable particle size. Morphological studies confirmed nanosponges formation and drug dispersion. In vitro data suggested extended release. This study establishes nanosponges nanogel as a viable platform for controlled bacitracin delivery. The sustained release offers potential for improved infection management. This research contributes valuable data to antibiotic drug delivery, paving the way for further study