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Abstract

Background: Periodontitis has been linked to adverse pregnancy outcomes , but its impact on neonatal inflammation remains unclear.
Objective: To investigate the relationship between maternal periodontitis and neonatal inflammation .
Methods: A prospective cohort study was conducted among pregnant women with periodontitis and healthy controls. Maternal periodontal status was assessed, and neonatal cord blood was analyzed for inflammatory markers (IL-6 and TNF-α).
Results: Maternal periodontitis was associated with increased neonatal inflammatory markers (IL-6 and TNF-α) and lower birth weight. A positive correlation was found between maternal periodontal disease severity and neonatal inflammatory markers.
Conclusion: Maternal periodontitis is associated with increased neonatal inflammation , suggesting a potential link between maternal oral health and fetal development. These findings highlight the importance of prenatal periodontal care in reducing adverse birth outcomes.