DefinePK

Abstract

Background:Diabetes Mellitus is a metabolic disease with significant health impacts, including cardiovascular disease and retinopathy, exacerbated by uncontrolled glucose levels. The onset of Diabetic Retinopathy (DR) is closely associated with oxidative damage, inflammation, and several proangiogenic cytokines. Chemerin and apelin are pleiotropic peptide cytokine and it is involved in adipogenesis, glucose metabolism and inflammation.
Objective: To assess the levels of inflammatory marker chemerin and apelin in T2DM patients with and without diabetic retinopathy.
Materials and Methods:This study was conducted at St.Peters Medical College Hospital & Research Institute,Hosur,Tamilnadu. Duration of study period was 1year. Totally 110 healthy control, and 110 patients without DR and 110 patients with DR were included. Serum samples were tested for chemerin and apelin by ELISA method. Biochemical parameters and ophthalmological examination findings of the participants were recorded.
Results and Discussion:In this study,we recruited 330 participants, including110 healthy individuals in group 1, 110 patients T2DM without DR in group2 and 110 T2DM with DR in group 3. Out of 110 DR ,77 were males (70%) and 33 (30%) females. Serum chemerin andapelin level was significantly higher in group 1 than in group2 and group 3.
Conclusion: patients with T2DM with DR showed higher Serum chemerin and apelin levels than those with T2DM without DR and healthy individuals. High levels of chemerin and apelin paved the pathogenesis diabetic retinopathy by enhancing inflammation, insulin resistance and angiogenesis factor. Early diagnosis of T2DM provides better treatment and reduce risk of diabetic retinopathy.