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Abstract

Aim: The objective of this work was to enhance the anti-inflammatory properties of silymarin by developing and refining an Orodispersible tablet formulation loaded with nanoparticles.
Objective: This study report focuses on the formulation creation and optimization of an orodispersible tablet containing silymarin for its anti-inflammatory properties.
Background: By improving solubility and absorption, drug delivery methods utilizing nanoparticles can aid in overcoming these constraints. Orodispersible pills dissolve and disintegrate quickly in the mouth without the need for water, resulting in a quicker start of action.
Method: Direct compression was then used to incorporate these nanoparticles into orodispersible tablets that contained superdisintegrants and sweeteners. The tablet formulation was systematically optimized using a box-behnken design based on responses such as friability, hardness, wetting time, and disintegration time.
Result: Formulation F3, which has 5% of crospovidone as a superdisintegrant, exhibited maximum drug release, or 98.5%, after 15 minutes. The anti-inflammatory potential was assessed in rats with paw edema caused by carrageenan. After three hours, the 400 mg/kg dose showed a significant 48% inhibition; after three hours, the impact rose to 52%.
Conclusion: Overall, the creation of orodispersible silymarin nanoparticle tablets holds out hope for enhancing silymarin's anti-inflammatory properties through the complementary use of fast-dissolving tablet and nanoencapsulation technologies