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4-Amino pyrimidine derivatives: design, synthesis, antiviral, and antibacterial investigation

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Title: 4-Amino pyrimidine derivatives: design, synthesis, antiviral, and antibacterial investigation

Authors: Moktar M. Aburzeza, Ismail M. Awheda, Wesam A. Kollab, Alkhansa O. Abdulnnour

Journal: Journal of Neonatal Surgery

HEC Recognition History
Category From To
Y 2023-07-01 2024-09-30
Y 2022-07-01 2023-06-30

Publisher: EL-MED-Pub Publishers

Country: Pakistan

Year: 2025

Volume: 14

Issue: 26S

Language: en

Keywords: Antimicrobial

Categories
Antiviral Agents (12) Microbiology (14542) Organic Chemistry (862) Pharmacology (22872) Medicinal Chemistry (1249)

Abstract

Numerous novel 4-Amino-pyrimidine-5-carbonitrile, 1,3-thiazine, and 1,3,4-thiadiazole derivatives were produced using 2-pyridin-4-ylmethylene) hydrazine-1-carboximidamide as the main starting material. In vitro tests were used to evaluate antiviral and antibacterial qualities. The synthesised compounds were characterised by elemental analysis, FT-IR, 1H NMR, and LC-MS spectral investigations.

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